Severe Bacterial Infections

Over 120,000 hip or knee replacements are done annually in Australia and about 3,900 new prosthetic joint infections (PJI) are diagnosed in Australia each year. PJIs are difficult to treat, expensive, and negatively impact patients' quality of life. Current treatment guidelines for PJIs lack evidence-based approaches. The ROADMAP trial (RandOmised Arthroplasty infection worlDwide Multidomain Adaptive Platform trial) will compare the most common strategies in managing prosthetic joint infections, including optimal surgical strategies. The results will be directly translated into clinical guidelines and practice. Our vision is to improve the treatment success of prosthetic joint infections, to improve patient-reported joint function and quality of life, and to reduce PJI related direct health care costs.

Click here to find out more about the ROADMAP trial.

Bacteremia is the presence of bacteria in the bloodstream. Bacteria may enter the circulation through medical procedures, certain tissue infections or even in everyday life through vigorous toothbrushing or minor cuts in the skin. Most of the time, this is harmless, but if our immune system fails to defeat the bacteria, they can proliferate, spread to other organs and tissues, and cause severe infection and sepsis. We then depend on antibiotics to fight the bacteria. Staphylococcus aureus is one of the most dangerous bacteria causing bloodstream infection. Some of them have become resistant to certain antibiotics, and we need to find the medication that works best. The SNAP trial (Staphylococcus aureus Network Adaptive Platform trial) is comparing the effect of different antibiotics on bloodstream infections caused by Staphylococcus aureus to find the best treatment and to save lives. The SNAP trial is co-led by Prof Josh Davis and is a collaboration with the Doherty Institute at the University of Melbourne, along with over 120 hospitals across Australia, New Zealand, Singapore, Canada, Israel, the United Kingdom, South Africa and Europe.

Click here to visit the official website for the SNAP trial. 

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